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　　同时与五位女友交往的五劈男——星野一彦由于欠下巨额债务，两周后将被抓上“那辆巴士”，带往一个神秘的地方以恐怖未知的方式偿债，再也无法回来。在这两周里，债主派出身高与体重均为一百八的彪悍女茧美监视星野。星野得到债主同意，在上巴士前可以与五位女友一一道别。为了让对方彻底死心，星野骗对方，自己决定与茧美结婚。所以，五次“我们分手吧”，换来了人生不一样的结局。

　　本季改编自原著系列中的第四本《Spook Street》。
　　一场爆炸拉开序幕，随之引爆了一系列惊人的秘密，动摇了Slough House本就不太稳定的关系。

Code of Silence introduces us to Deaf catering worker, Alison Woods. She’s struggling to make ends meet, juggling two jobs, in a police canteen and a local bar, while also doing her best to support her Deaf mum, Julie. When DC Ashleigh Francis calls on Alison to lip read the conversations of some dangerous criminals, she is plunged into a new and exhilarating world.                                    
                               　　Alison’s interpretation of the gang's clandestine meetings quickly become key to unlocking the police investigation. But Alison's feelings about the case become complicated when she finds herself drawn to Liam, one of the main suspects. Alison knows she's putting herself at risk by agreeing to work with the police, and when things threaten to spill over into her personal life, she knows she should step away. But Alison can’t let go…

　　Sydney finds herself face-to-face with her long-lost mother, Irina Derevko, whose intentions for her daughter are made chillingly clear. However, Sydney manages to escape and rejoin Jack and Will in their escape from Taiwan. After arriving back in Los Angeles, Sydney continues her search for Vaughn, not knowing if he is dead or alive after being swept away by a wall of water in Taipei. Will's life is forever changed when he learns the truth about SD-6 and Sydney's life as a double agent. Also, Dixon must decide whether or not to inform Sloane of Sydney's suspicious activities. But Jack intervenes and covers for Sydney who later finds Vaughn who helps her try to track down her mother Irina who's searing for a Rimbaldi artifact called 'the Bible.'

在第四季中，Noah、Helen、Alison和Cole远离了彼此，生活在自己的圈子中。想当初他们的命运是如此纠缠，现在他们却日渐疏远。每个角色都有了新的爱情，但他们都面临艰难的抉择：他们是否已经做好了彻底忘记过去的准备？在新的开始和悲剧的结局之间，他们是否还有获得救赎和原谅的可能？Sanaa Lathan本季扮演Noah工作的特效学校的校长Jenelle，为人非常冷酷。学校的管理层和教职员工都对她不满，每件事都在和她作对。Ramon Rodriguez扮演海军陆战队退伍老兵Ben，目前为退伍军人健康管理局工作。他有一定程度的创伤后应激障碍症，担任悲伤心理治疗师的Alison很快和他有了交集。Russell Hornsby、Christopher Meyer、Amy Irving和Phoebe Tonkin在第四季中客座演出。

　　地方新闻社·新神奈川日报记者泽村政彦（松田龙平 饰）收到了「肇事逃逸事件」的独家新闻素材中提到了痛失丈夫的森本敦子（小芝风花 饰）是肇事者。
　　久违的独家新闻让政彦干劲十足，但却被他大学同期的网络新闻主编 ·三反园（松山研一 饰）指出这是由同事桐野（筒井道隆 饰）所设计的不实报道，政彦追寻着消失了踪影的桐野...

　　《西部世界》主创乔纳森·诺兰＆丽莎·乔伊夫妇将打造未来题材新剧《外围》(The Peripheral)，基于William Gibson所著同名小说，两人的制片公司Kilter Films和亚马逊联合制作，如果剧本可行，将直接预定整季。设定在未来的美国，科技开始潜移默化地改变社会，女主Flynne Fisher发现了与一个不同现实的隐藏联系，以及她自己的黑暗的未来。
　　斯科特·B·史密斯(《绝地计划》《恐怖废墟》)编写剧本，他也担任执行制片，文森佐·纳塔利(《西部世界》《汉尼拔》《人兽杂交》)执导。